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Mesoporous dealuminated zeolites are used as hosts for ibuprofen. This drug experiences high mobility when confined in mesopores, which is largely dependent on the water content. Zeolites are materials that are naturally hydrated under ambient conditions. Nitrogen adsorption and X-ray diffraction (XRD) show that the samples with the content of ibuprofen up to 38% have the guest phase residing only in mesopores. 1H and 13C MAS NMR studies of samples in ambient conditions, after dehydration, and in hydration prove the impact of water for increased mobility of ibuprofen. Increased mobility of the introduced phase was also detected for samples with no water content. It was ascribed to ibuprofen located outside mesopores, which experiences a prolonged time of cooling to room temperature. This phenomenon is important for all the future uses of the melting method in guest–host systems and the future use of zeolites for biomedical applications.

The Impact of Hydration and Dehydration on the Mobility and Location of Ibuprofen Molecules in the Voids of Ultra-Stable Zeolite Y