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Recent burgeoning development in material science has introduced a 3D-printable, nanohybrid composite resin restorative material. However, its performance has not yet been investigated. This study evaluates the stain susceptibility and efficacy of different stain removal techniques. A total of 120 labial veneers were fabricated using milling ( n = 60) and SLA 3D-printing ( n = 60). Based on the immersion media: coffee, tea and artificial saliva, each group was divided into three sub-groups ( n = 20). Stain susceptibility was evaluated by calculating color difference (∆E 00 ) at 12 and 24 days using a spectrophotometer against black and white backgrounds. Collected data were analyzed with ANOVA and Tukey's post hoc test ( p &lt; 0.05). A significant interaction effect was found between the staining mediums and fabrication methods in both black and white backgrounds ( p &lt; 0.001). 3D-printed restorations showed significantly higher stain susceptibility than milled restorations ( p &lt; 0.001). Prolonged immersion time increased the color difference in both groups. In-office bleaching was more effective in stain removal in both 3D-printed and milled restoration groups. The susceptibility of the presented novel 3D-printed restorative material to color changes in different immersion mediums was clinically not-acceptable. The clinicians might expect the need to replace the restoration after 1-2 years and thus, recommendation for the use of such a material as a permanent restoration cannot be made but rather as a long-term temporary restoration.

Stain Susceptibility of 3D-Printed Nanohybrid Composite Restorative Material and the Efficacy of Different Stain Removal Techniques: An In Vitro Study