English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The aim of this study was to verify the effect of the formulation on the release kinetics of active substances from preparations containing iron ions using in-line conductivity measurements. A simple, fast method was developed and may be applied for detailed evaluation of some kinetics factors obtained from the release data. Four different equations were used: zero-order equation, first-order equation, models: Korsmeyer⁻Peppas and Hixson⁻Crowell. Values of the determined half-time release for zero and first-order kinetic models ranged from 11.56 to 89.97 min. In the case of analysis according to these typical models, the values of the square root of the correlation coefficients were included between 0.9916 and 0.9995. The results transformed for the Hixson⁻Crowell model as constant release Ks, ranged between 0.0160 and 0.0437. The values of the respective calculated squares of the correlation coefficient ranged from 0.9933 to 0.9959. The determined release rate constants according to the Korsmeyer⁻Peppas model were between 0.0023 and 0.1630. The coefficients 'n' of the Korsmeyer⁻Peppas equation did not exceed 1.2 with the corresponding r² values 0.9408⁻0.9960. Obtained results confirmed that the method is applicable for evaluation of selected drug compositions containing iron ions.

Conductomeric Evaluation of the Release Kinetics of Active Substances from Pharmaceutical Preparations Containing Iron Ions