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A new etherified 1-O-acetylbritannilactone (ABL) analogue 2 was semi-synthesized by a mild etherification reaction. The structure of the newly synthesized analogue was identified by 1H-NMR, 13C-NMR and HR-ESI-MS analysis. 2 exhibited similar cytotoxicity against HCT116, SGC-7901 and HeLa human cancer cell lines with ABL

(S)-4-[(3aR,4S,7aR)-4-Methoxy-6-methyl-3-methylene-2-oxo-2,3,3a,4,7,7a-hexahydrobenzofuran-5-yl]pentyl Acetate