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Poria cocos , called fuling, is a famous tonic in traditional Chinese medicine that reportedly possesses various pharmacological properties, including anti-inflammation and immunomodulation. However, few studies have investigated the effects of  P. cocos  on allergic diseases, such as allergic asthma. Allergic asthma is caused primarily by Th2 immune response and characterized by airway inflammation. This study first demonstrated the anti-allergic and anti-asthmatic effects of  P. cocos  extract (Lipucan ® ).  P. cocos  extract distinctly exhibited reduced inflammatory cell infiltration in the peribronchial and peribronchiolar regions compared to the asthma group in the histological analysis of pulmonary tissue sections. Prolonged  P. cocos  extract administration significantly reduced eosinophil infiltration, PGE2 levels, total IgE, and OVA-specific IgE. Moreover,  P. cocos  extract markedly suppressed Th2 cytokines, IL-4, IL-5, and IL-10. On the other hand,  P. cocos  extract significantly elevated IL-2 secretion by Th1 immune response. In addition,  P. cocos  extract elevated the IFN-γ level at a lower dose. We also observed that  P. cocos  extract increased the activity of NK cells. Our results suggest that  P. cocos  extract remodels the intrinsic Th1/Th2 response to prevent or alleviate allergy-induced asthma or symptoms.

Poria cocos Modulates Th1/Th2 Response and Attenuates Airway Inflammation in an Ovalbumin-Sensitized Mouse Allergic Asthma Model