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Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A &gt; T and rs2274908 G &gt; A) in CAD. We conclude that the AT genotype and the T allele of the rs2274907 A &gt; T is associated with Cad in the south Indian population. Our results indicated that the rs2274907 SNP may be associated with CAD in this population. This finding needs further validation in well-designed and large-sample size studies before being introduced in clinical settings.

journal of personalized medicine

Reply to Comment: Evaluation of the Association of Omentin 1 rs2274907 A &gt; T and rs2274908 G &gt; A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case–Control Study