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Triangularia mangenotti was analyzed for the production of secondary metabolites, resulting in the isolation of known zopfinol ( 1 ) and its new derivatives zopfinol B-C ( 2-4 ), the 10-membered lactones 7-O-acetylmultiplolide A ( 5 ) and 8-O-acetylmultiplolide A ( 6 ), together with sordarin ( 7 ), sordarin B ( 8 ), and hypoxysordarin ( 9 ). The absolute configuration of 1 was elucidated by the synthesis of MPTA-esters. Compound 1 showed antimicrobial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and the fungus Mucor hiemalis . While 4 was weakly antibacterial, 3 showed stronger antibiotic activity against the Gram-positive bacteria and weak antifungal activity against M. hiemalis and Rhodotorula glutinis . We furthermore observed the cytotoxicity of 1 , 3 and 4 against the mammalian cell lines KB3.1 and L929. Moreover, the new genus Pseudorhypophila is introduced herein to accommodate Triangularia mangenotii together with several species of Zopfiella - Z. marina , Z. pilifera , and Z. submersa . These taxa formed a well-supported monophyletic clade in the recently introduced family Navicularisporaceae, located far from the type species of the respective original genera, in a phylogram based on the combined dataset sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and fragments of the ribosomal polymerase II subunit 2 ( rpb2 ) and β-tubulin ( tub2 ) genes. Zopfiella submersa is synonymized with P. marina due to the phylogenetic and morphological similarity. The isolation of zopfinols 1 - 4 and sordarins 7 - 9 confirms the potential of this fungal order as producers of bioactive compounds and suggests these compounds as potential chemotaxonomic markers.

Three New Derivatives of Zopfinol from Pseudorhypophila Mangenotii gen. et comb. nov.