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The purpose of the present investigation was to study the possible differences between men and women in muscle damage indices and oxidative stress biomarkers in response to eccentric exercise. Ten males and ten females performed a bout of eccentric exercise using an isokinetic dynamometer. Muscle damage indices (i.e., isometric torque, range of movement, delayed onset muscle soreness, and creatine kinase (CK)) and oxidative stress biomarkers (i.e., protein carbonyls and glutathione) were measured before and 48 h after eccentric exercise. No significant main effect of group or time–group interaction was found for muscle damage indices and oxidative stress biomarkers. However, the main effect of time was significant for all measured parameters. The findings of the present investigation indicate that eccentric exercise caused muscle damage and oxidative stress (i.e., protein and glutathione oxidation) in both males and females with no significant differences between the two groups. It is concluded that there are no differences between males and females regarding muscle damage and oxidative stress after eccentric exercise.

The Effects of Eccentric Exercise on Muscle Damage and Blood Redox Status in Men and Women