English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The detection of dopamine, an important neurotransmitter in the central nervous system, is relevant because low levels of dopamine can cause brain disorders. Here, a novel electrochemical platform made of a hydrogel–graphene oxide nanocomposite was employed to electrochemically determine simultaneously dopamine (DA) and ascorbic acid (AA). Unlike previous work, where the base electrode is modified, the active material (graphene oxide, GO) was dispersed in the hydrogel matrix, making an active nanocomposite where the electrochemical detection occurs. The GO, hydrogel and nanocomposite synthesis is described. Dynamic Light Scattering, UV-visible and FTIR spectroscopies showed that the synthesized GO nanoparticles present 480 nm of diagonal size and a few sheets in height. Moreover, the polymer swelling, the adsorption capacity and the release kinetic of DA and AA were evaluated. The nanocomposite showed lower swelling capacity, higher DA partition coefficient and faster DA release rate than in the hydrogel. The electrochemical measurement proved that both materials can be employed to determine DA and AA. Additionally, the nanocomposite platform allowed the simultaneous determination of both molecules showing two well separated anodic peaks. This result demonstrates the importance of the incorporation of the nanomaterial inside of the hydrogel and proves that the nanocomposite can be used as a platform in an electrochemical device to determinate DA using an unmodified glassy carbon electrode.

journal of composites science

Hydrogel-Graphene Oxide Nanocomposites as Electrochemical Platform to Simultaneously Determine Dopamine in Presence of Ascorbic Acid Using an Unmodified Glassy Carbon Electrode