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The most serious disturbance of the nutritional status is neoplastic cachexia. The main factor contributing to the development of cachexia is the ongoing inflammatory process. The gene associated with the development of the inflammatory response is ITGAM . Therefore, the aim of the study was to assess the relationship between a single nucleotide polymorphism (SNP)-323G&gt;A of the ITGAM gene and the occurrence of nutritional disorders in patients undergoing radiotherapy (RT) due to head and neck cancers (HNC).

journal of clinical medicine

Polymorphism of The Regulatory Region of the ITGAM Gene (-323G&gt;A) as a Novel Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation Therapy