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Although blood is the basic test material to monitor levels of antipsychotic drugs in a person's system, saliva could serve as a more convenient test material. Therefore, the aim of this novel study was to determine the correlations between the salivary levels of olanzapine and quetiapine (and their metabolites: N-demethyl olanzapine and norquetiapine) and the patient's sex and age, dose level, and the time of sampling. The study involved two groups of patients: 21 female patients starting treatment immediately after being admitted to the hospital and 36 male and female nursing home residents, long-time users of the studied drugs. Women had lower levels of the tested analytes than men. Quetiapine levels in the saliva of people starting the treatment showed a positive correlation with the age of the patients and a strong positive correlation with the dose level. The saliva levels of olanzapine showed a strong correlation with its metabolite in patients who had recently started treatment. Among long-time users of this drug, salivary levels differed significantly before and after administration. In conclusion, the results indicate that there is a possibility of using saliva as a material for monitoring quetiapine or olanzapine concentrations, especially in people starting treatment.

Effects of Age, Drug Dose, and Sampling Time on Salivary Levels of Olanzapine, Quetiapine, and Their Metabolites