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The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery, but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for somatostatin (SST 1-5 ) and dopamine (DRDs) providing a rationale for the use of dopamine agonists and somatostatin analogues. Here, we systematically assessed SST 1-5 and DRDs expression by real-time quantitative PCR (RT-qPCR) in a large group of patients with NFPTs ( n = 113) and analyzed their potential association with clinical and molecular aggressiveness features. SST 1-5 expression was also evaluated by immunohistochemistry. SST 3 was the predominant SST subtype detected, followed by SST 2 , SST 5 , and SST 1 . DRD2 was the dominant DRD subtype, followed by DRD4, DRD5, and DRD1. A substantial proportion of NFPTs displayed marked expression of SST 2 and SST 5 . No major association between SST s and DRDs expression and clinical and molecular aggressiveness features was observed in NFPTs.

journal of clinical medicine

Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features