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Background: Sleep-disordered breathing (SDB) is a widespread comorbidity in patients with chronic heart failure (HF) and may have a deleterious effect on the pathogenesis of HF. We aimed to evaluate the prognostic role of polysomnography parameters in HF patients with previous decompensation. Methods: 123 patients were included in the prospective cohort study. In addition to the standard examination, all patients underwent polysomnography (PSG). Results: The Kaplan−Meier analysis showed the incidence of the combined endpoint differs between LVEF categories ≤25.5% vs. &gt;25.5% (χ2 = 9.6, log rank p = 0.002), NTpro-BNP &gt; 680 vs. ≤680 pg/mL (χ2 = 12.7, log rank p = 0.001), VO2peak categories &lt;16 vs. ≥16 mL/min/kg (χ2 = 14.2, log rank p = 0.001), VE/VCO2 slope ≥38.5 vs. &lt;38.5 (χ2 = 14.5, log rank p = 0.001), wake after sleep onset &gt;40 min vs. ≤40 min (χ2 = 9.7, log rank p = 0.03), and sleep stage 2 (S2) &lt;44% vs. ≥44% (χ2 = 12.4, log rank p = 0.001). Conclusion: Among the PSG parameters, WASO &gt; 40 min and S2 &lt; 44% were associated with a combined endpoint in patients with previous decompensation of HF. Moreover, higher NT-proBNP and VE/VCO2 slope, lower LVEF, and VO2peak were also independent factors of a poor prognosis.

The Prognostic Role of Polysomnography Parameters in Heart Failure Patients with Previous Decompensation