English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The edible fungus Tremella fuciformis was shown to have a high molecular weight (1.87 × 10 3 kDa) bioactive polysaccharide, denoted as TFP-F1. Monosaccharide composition and NMR analysis of the polysaccharide and its derivatives indicated it contained fucose (Fuc p ), xylose (Xyl p ), mannose (Man p ), and glucuronic acid (GlcA p ) in a ratio of 0.9:1.0:3.2:1.2. Using IR, NMR, and GC-MS spectroscopic data, the structure of TFP-F1 was elucidated as {→3)-[ β -D-GlcA p -(1→2)]- α -D-Man p -(1→3)- α -D-Man p -(1→3)-[ α -L-Fuc p -(1→2)- β -D-Xyl p -(1→2)]- α -D-Man p -(1→} n , with partial acetylation of C6-OH in mannoses. Furthermore, at a concentration of 1 μg/mL, TFP-F1 was found to stimulate the secretion of TNF-α and IL-6 in J774A.1 macrophage cells in vitro via interaction with toll-like receptor 4 (TLR4). The removal of O -acetyl groups led to the loss of immunomodulatory activities, demonstrating that O -acetyl groups play an essential role in enhancing the production of pro-inflammatory cytokines.

An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation