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Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of  p27  and  cdk2  in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of  p27  and  CDK2  in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes.  p27 , but not  cdk2 , exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans.  p27  is drastically downregulated by aging in subcutaneous WAT (scWAT), but not in gonadal WAT, of female mice. Obesity upregulates  p27  and  cdk2  expression in scWAT, but not in other fat depots of aged mice. In humans, a significant upregulation of  p27  was observed in visceral WAT of subjects with obesity. Taken together, these results show a differential adipose depot-dependent regulation of  p27  and  cdk2  in aging and obesity, suggesting that p27 and cdk2 could contribute to the adipose-tissue depot’s metabolic differences. Further studies are necessary to fully corroborate this hypothesis.

Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity