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Biotransformation of four bioactive phenolic constituents from licorice, namely licoisoflavanone ( 1 ), glycyrrhisoflavone ( 2 ), echinatin ( 3 ), and isobavachalcone ( 4 ), was performed by the selected fungal strain Aspergillus niger KCCM 60332, leading to the isolation of seventeen metabolites ( 5 - 21 ). Structures of the isolated compounds were determined on the basis of extensive spectroscopic methods, twelve of which ( 5 - 7 , 10 - 17 and 19 ) have been previously undescribed. A series of reactions including hydroxylation, hydrogenation, epoxidation, hydrolysis, reduction, cyclization, and alkylation was observed in the biotransformation process. All compounds were tested for their cytotoxic activities against three different human cancer cell lines including A375P, MCF-7, and HT-29. Compounds 1 and 12 exhibited most considerable cytotoxic activities against all the cell lines investigated, while compounds 2 and 4 were moderately cytotoxic. These findings will contribute to expanding the chemical diversity of phenolic compounds, and compounds 1 and 12 may serve as leads for the development of potential cancer chemopreventive agents.

Biotransformation of the Phenolic Constituents from Licorice and Cytotoxicity Evaluation of Their Metabolites