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Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of  Stizolophus balsamita  growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus  Stizolophus . The MTT assay was employed to study in vitro cytotoxic effects of the taxifolin against human fibroblasts. We also evaluate the possible biological properties/cosmetic effects of  Stizolophus balsamita  extract and taxifolin on the human skin. Sixty healthy Caucasian adult females with no dermatological diseases were investigated. We evaluate the effects of  S. balsamita  extract and taxifolin on skin hydration and transepidermal water loss (TEWL). It was revealed that  S. balsamita  extract might decrease TEWL level and fixed the barrier function of the epidermis. The presence of bioactive phytochemical constituents in  S. balsamita  inflorescences makes them a valuable and safe source for creating new cosmetics and medicines.

international journal of molecular sciences

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters