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Ca 2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca 2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca 2+ pool. Protozoan parasites such as Plasmodium falciparum , Toxoplasma gondii , and Trypanosoma cruzi display a Ca 2+ signaling toolkit with similarities to higher eukaryotes, including the participation of mitochondria in Ca 2+ -dependent signaling events. This review summarizes the most recent knowledge in mitochondrial Ca 2+ signaling in protozoan parasites, focusing on the mechanism involved in mitochondrial Ca 2+ uptake by pathogenic protists.

Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria