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Ferric nitrobindins (Nbs) selectively bind NO and catalyze the conversion of peroxynitrite to nitrate. In this study, we show that NO scavenging occurs through the reductive nitrosylation of ferric  Mycobacterium tuberculosis  and  Homo sapiens  nitrobindins ( Mt -Nb(III) and  Hs -Nb(III), respectively). The conversion of  Mt -Nb(III) and  Hs -Nb(III) to  Mt -Nb(II)-NO and  Hs -Nb(II)-NO, respectively, is a monophasic process, suggesting that over the explored NO concentration range (between 2.5 × 10 −5  and 1.0 × 10 −3  M), NO binding is lost in the mixing time (i.e.,  NO  k  on  ≥ 1.0 × 10 6  M −1  s −1 ). The pseudo-first-order rate constant for the reductive nitrosylation of  Mt -Nb(III) and  Hs -Nb(III) (i.e.,  k ) is not linearly dependent on the NO concentration but tends to level off, with a rate-limiting step (i.e.,  k  lim ) whose values increase linearly with [OH − ]. This indicates that the conversion of  Mt -Nb(III) and  Hs -Nb(III) to  Mt -Nb(II)-NO and  Hs -Nb(II)-NO, respectively, is limited by the OH − -based catalysis. From the dependence of  k  lim  on [OH − ], the values of the second-order rate constant  k  OH−  for the reductive nitrosylation of  Mt -Nb(III)-NO and  Hs -Nb(III)-NO were obtained (4.9 (±0.5) × 10 3  M −1  s −1  and 6.9 (±0.8) × 10 3  M −1  s −1 , respectively). This process leads to the inactivation of two NO molecules: one being converted to HNO 2  and another being tightly bound to the ferrous heme-Fe(II) atom.

NO Scavenging through Reductive Nitrosylation of Ferric Mycobacterium tuberculosis and Homo sapiens Nitrobindins