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Photothermal therapy possesses great advantages for the treatment of drug-resistant tumors. Herein, Near Infrared (NIR)-triggered photothermal nanoparticles were developed through loading indocyanine green (ICG), a kind of NIR dye, into amino group-modified silica nanoparticles (SiO 2 -NH 2 NPs). SiO 2 -NH 2 NPs were prepared with immobilization of the amino groups into the framework of silica nanoparticles (SiO 2 NPs) by employing (3-aminopropyl)-triethoxysilane (APTES). Before and after the modification of the amino group, the particle sizes of SiO 2 NPs showed similar value, around 100 nm. ICG was further adsorbed into SiO 2 -NH 2 NPs by electrostatic attraction to enable SiO 2 -NH 2 @ICG NPs as a kind of photothermal agent. The loading rate of ICG to SiO 2 -NH 2 was greatly increased compared to unmodified SiO 2 , and the stability of ICG was also improved. Moreover, the SiO 2 -NH 2 @ICG NPs exhibited efficient photothermal effects due to ICG transforming laser power into local heat through the connected ICG, when NIR laser irradiation turned on for a couple of minutes. Finally, the in vitro antitumor efficacy of SiO 2 -NH 2 @ICG NPs was investigated by recording cell proliferation rate and further chronicled the apoptotic morphology evidence by a Calcein-AM/PI fluorescent staining assay, indicating the efficient photothermal targeted therapy for the HepG2 tumor cells.

Indocyanine Green Loaded Modified Mesoporous Silica Nanoparticles as an Effective Photothermal Nanoplatform