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Acne is an inflammatory skin disorder in puberty with symptoms including papules, folliculitis, and nodules. Propionibacterium acnes ( P. acnes ) is the main anaerobic bacteria that cause acne. It is known to proliferate within sebum-blocked skin hair follicles. P. acnes activates monocytic cell immune responses to induce the expression of proinflammatory cytokines. Although the anti-inflammatory function of the Laurus nobilis ( L. nobilis ) extract (LNE) on several immunological disorders have been reported, the effect of LNE in P. acnes -mediated skin inflammation has not yet been explored. In the present study, we examined the ability of the LNE to modulate the P. acnes -induced inflammatory signaling pathway, and evaluated its mechanism. LNE significantly suppressed the expression of P. acnes -mediated proinflammatory cytokines, such as IL-1β, IL-6, and NLRP3. We also found that LNE inhibited the inflammatory transcription factor NF-κB in response to P. acnes . In addition, eucalyptol, which is the main constituent of LNE, consistently inhibited P. acnes -induced inflammatory signaling pathways. Moreover, LNE significantly ameliorated P. acnes -induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of P. acnes -induced skin inflammation.

Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol