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From a series of (1 R , 1 S )-1[β-(phenylalkoxy)-(phenetyl)]-1 H -pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca 2+ release and store-operated Ca 2+ entry (SOCE) (IC 50 25 μM) on the PLP-B lymphocyte cell line. A successful resolution of (±) 1-phenyl-2-(1 H -pyrazol-1-yl)ethan-1-ol has been developed by using the method of "half-concentration" in the presence of (+)-(1 S )- or (-)-(1 R )-CSA.

international journal of molecular sciences

Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors