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Youth suicidality is considerably prevalent in low- and middle-income countries, including Benin. Factors such as psychosocial distress, socio-environmental factors, and health risk behaviors are associated with suicidality. However, little is known about how these factors co-occur in these countries. An analysis of these factors taken together would help to identify the profiles most at risk and better target prevention policies. Our study aimed to identify profiles related to these factors and their association with suicidality among adolescents in Benin. Data from the 2016 Global School-Based Student Health Survey were used, and factors related to lifestyle (tobacco and alcohol consumption and physical activity), physical violence, parental support, and psychological distress were studied. Latent class analysis was used to identify the profiles, and a modified Poisson regression with generalized estimating equations, adjusted for sociodemographic characteristics, was performed to assess the association between these profiles and suicidality. The survey results show that globally, 13.8% of the adolescents (n = 2536) aged 11 to 18 had thought about suicide, 15.6% had planned suicide, and 15.6% had attempted suicide. Four profiles were identified: a low-risk group, one with psychological distress problems, a group with violence problems, and one with alcohol, tobacco, and violence problems. The risk of suicidality, in terms of ideation, planning, or attempting, was higher for adolescents in Profiles 2, 3, and 4 than those in Profile 1 ( p &lt; 0.05). Adolescents in Profile 2 were particularly affected by this increased risk (prevalence ratio (PR) for ideation = 1.13, 95% CI = 1.03-1.23; PR for planning = 1.12, 95% CI = 1.04-1.22; PR for attempting = 1.09, 95% CI = 1.01-1.17). This study highlights the typical profiles that may be linked with suicidality among adolescents in Benin. A holistic consideration of these factors could help in planning better preventive measures to reduce suicidality among adolescents in Benin.

Using Latent Class Analysis to Identify Health Lifestyle Profiles and Their Association with Suicidality among Adolescents in Benin