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This study investigated the effects of home-based nutritional and telemedicine-based resistance exercise interventions on improving body composition, blood biochemistry, and lower-limb functional performance. In total, 66 obese patients with mild-to-moderate knee osteoarthritis were randomly divided into a diet control group (D), elastic band resistance exercise group (E), and diet control plus elastic band exercise group (D + E). Each group was supervised by a clinical dietitian and follow-up was conducted via telephone calls or a communication application to track the participants' progress. After 12 weeks of intervention, the D ( p &lt; 0.001) and D + E ( p &lt; 0.001) groups achieved significant weight loss. The D + E group exhibited a significant reduction in body fat relative to the D ( p = 0.019) and E ( p = 0.012) groups. Compared with the D ( p = 0.002) and E ( p = 0.019) groups, the D + E group achieved significant improvements in the timed up-and-go test and Western Ontario and McMaster Universities Osteoarthritis total scale. The D + E group experienced significant improvements in total cholesterol ( p = 0.001), low-density lipoprotein cholesterol ( p = 0.01), and triglyceride levels ( p = 0.007) relative to other groups. In conclusion, individual diet control intervention combined with telemedicine-based resistance exercise intervention significantly improved the body composition, blood biochemistry, and lower-limb functional performance of the investigated population with comorbid conditions.

international journal of environmental  research and public health/international journal of environmental research and public health

Effects of Diet Control and Telemedicine-Based Resistance Exercise Intervention on Patients with Obesity and Knee Osteoarthritis: A Randomized Control Trial