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This study investigated the association between physical exercise and cognitive function in Koreans aged 45 years or above without dementia. Data from the 2006 to 2018 Korean Longitudinal Study of Aging (KLoSA) were used. The general characteristics of the study population were investigated using analysis of variance (ANOVA). The association between total exercise time per week and cognitive function, measured based on the Mini-Mental State Examination (MMSE) scores, was investigated using the generalized estimating equation (GEE) model. Subgroup analysis was conducted based on age, educational level, and marital status. A total of 8888 participants were investigated, of which 5173 (58.2%) individuals did not exercise regularly. Among participants who did exercise, 676 (7.6%) individuals were categorized into the Q1, 1157 (13.0%) into the Q2, 908 (10.2%) into the Q3, and 974 (11.0%) into the Q4 group. The mean MMSE score was 26.81 ± 3.17. Compared to the 'no' exercise group, better MMSE scores were found in the Q1 (β: 0.3523, p ≤ 0.0001), the Q2 (β: 0.2011, p ≤ 0.0001), the Q3 (β: 0.4075, p ≤ 0.0001), and the Q4 groups (β: 0.3144, p ≤ 0.0001) after adjustment. The magnitude of this association was stronger in participants aged 65 years or above and in single or separated individuals. The findings of this study confirm a positive association between physical exercise and MMSE scores in the middle aged and elderly.

The Relationship between Physical Exercise and Cognitive Function in Korean Middle Aged and Elderly Adults without Dementia