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Background : Patients with either osteoporosis or depression are prone to develop other diseases and require more medical resources than do the general population. However, there are no studies on health-related quality of life (HRQoL) and medical resource use by osteoporosis patients with comorbid depression. We conducted this study for clarifying it. Methods : This cross-sectional study from 2005 to 2010 (6 years) analyzed 9776 National Health and Nutrition Examination Survey (NHANES) patients &gt; 40 years old. Each patient was assigned to one of four groups: osteoporosis-positive (+) and depression-positive (+) (O + /D + ); O + /D - ; O - /D + ; O - /D - . We used multivariate linear and logistic regression model to analyze the HRQoL and medical resource use between groups. Results : The O + /D + group reported more unhealthy days of physical health, more unhealthy days of mental health, and more inactive days during a specified 30 days. The adjusted odds ratios (AORs) of O + /D + patients who had poor general health (7.40, 95% CI = 4.80-11.40), who needed healthcare (3.25, 95% CI = 2.12-5.00), and who had been hospitalized overnight (2.71, 95% CI = 1.89-3.90) were significantly highest. Conclusions : Low HRQoL was significantly more prevalent in D + /O + patients. We found that depression severity more significantly affected HRQoL than did osteoporosis. However, both diseases significantly increased the risk of high medical resource use.

international journal of environmental  research and public health/international journal of environmental research and public health

Health-Related Quality of Life and Medical Resource Use in Patients with Osteoporosis and Depression: A Cross-Sectional Analysis from the National Health and Nutrition Examination Survey