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Background:  The purpose of the present study was to elucidate the experiences of long-term oxygen therapy (LTOT) patients with a portable oxygen unit and to describe the patients’ self-assessed health-related quality of life (HRQoL).  Methods:  The study employed a prospective cross-sectional design. Data collection entailed two questionnaires, namely the MedTech20 (patients’ experience of the medical device in four areas) and EQ-5D (HRQoL). The informants consisted of patients ( n  = 148) treated with such a medical device and that were registered in Skåne University Hospital’s database, Medusa.  Results:  In the domain  Sense of security  the informant felt  the equipment reliable and safe to use  and expressed  a sense of control for the user . Regarding  Social participation , the responses did not indicate the device to  facilitate leisure activities ,  movement outside the homes ,  traveling  or  everyday tasks  to a larger extent. The respondents did express a reduced sense of  compromised integrity , with a minor effect on  Intimacy . With regards to  Convenience , the responses indicated the product to provide  Adaptability to personal needs . Overall, a strongly affected HRQoL ( Your current health condition,  EQ-VAS Md = 50 (IQR 36–70)) with strong correlation with EQ-5D was seen.  Conclusions:  Informants experienced the portable oxygen unit as reliable and safe to use while giving a sense of control over the disease itself. A minor impact on social participation was reported, except for a reduced sense of compromised integrity. The patients also reported a strongly reduced HRQoL.

LTOT Patients’ Experience of a Portable Oxygen Unit and Health-Related Quality of Life—A Cross-Sectional Study