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Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase ( CKM ) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM ( rs8111989 , c.*800A&gt;G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia ( n = 458) and Lithuania ( n = 235), and 500 healthy non-athlete subjects from Russia ( n = 291) and Lithuania ( n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success.

CKM Gene rs8111989 Polymorphism and Power Athlete Status