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Ovine litter size (LS) is an important trait showing variability within breeds. It remains largely unknown whether inbreeding depression on LS exists based on genomic homozygous regions, and whether the homozygous regions resulted from inbreeding are significantly associated with LS in sheep. We here reanalyze a set of single nucleotide polymorphism (SNP) chip of six breeds to characterize the patterns of runs of homozygosity (ROH), to evaluate inbreeding levels and inbreeding depressions on LS, and to identify candidate homozygous regions responsible for LS. Consequently, unique ROH patterns were observed among six sheep populations. Inbreeding depression on LS was only found in Hu sheep, where a significant reduction of 0.016, 0.02, and 0.02 per 1% elevated inbreeding F ROH4-8 , F ROH  &gt;  8 and the total inbreeding measure was observed, respectively. Nine significantly homozygous regions were found for LS in Hu sheep, where some promising genes for LS possibly via regulation of the development of oocytes ( NGF , AKT1 , and SYCP1 ), fertilization ( SPAG17 , MORC1 , TDRD9 , ZFYVE21 , ADGRB3 , and CKB ), embryo implantation ( PPP1R13B , INF2 , and VANGL1 ) and development ( DPPA2 , DPPA4 , CDCA4 , CSDE1 , and ADSSL1 ), and reproductive health ( NRG3 , BAG5 , CKB , and XRCC3 ) were identified. These results from the present study would provide insights into the genetic management and complementary understandings of LS in sheep.

Litter Size of Sheep (Ovis aries): Inbreeding Depression and Homozygous Regions