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NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating  KIR  genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between  KIR/HLA  genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14  KIR  genes,  HLA-Bw4 ,  HLA-C1 , and  HLA-C2  by PCR-single specific primer (SSP). Positive associations of the  KIR3DS1  gene (odds ratio (OR) 1.959,  p  = 0.021), G11 genotype (OR 19.940,  p  = 0.008), and  KIR3DS1/HLA-A Bw4   (OR 2.265,  p  = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448,  p  = 0.031) and  KIR3DL1/HLA-Bw4 Ile80   (OR 0.522,  p  = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the  KIR3DS1/HLA-A Bw4   genotype in PsV pathology.

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population