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Although many parametric studies have been conducted in developing standardized nasal geometry and analysing associated airflow dynamics, most of them are based on symmetrical nasal chambers assumption, while the inter-chamber variations due to the morphological asymmetry of the two nasal chambers are much less investigated. To address this issue, this paper presents an inter-chamber anatomical variability study by developing a shape comparison method to quantify inter-chamber anatomical differences. Then the anatomical deviation is correlated with the flow apportionment and the associated nanoparticle deposition patterns using CFD method. Results show that noticeable inter-chamber difference is observed especially in the inferior and middle passages where most inhaled flow is distributed to. Additionally, the shape of vestibule notch and septum deviation contributes to the discrepancy flow behaviour between two chambers. Consequently, these differences lead to variations in regional nanoparticle deposition, especially for 1 nm particles in the olfactory region, where the inter-chamber differences can reach up to 400%. Our results suggest that the inter-chamber anatomical variation should be considered when developing standardized nasal models.

Detailed Assessment of Nasal Inter-Chamber Anatomical Variations and Its Effect on Flow Apportionment and Inhalation Exposure Patterns