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Practical synthesis of 1,3-diaryl-substituted 3-isothiocyanatopropan-1-ones based on the reaction of chalcones with thiocyanic acid generated in situ by treatment of thiocyanate ammonium with dilute sulfuric acid has been developed.

Addition of Thiocyanic Acid to Chalcones: Practical Synthesis of 1,3-Diaryl-3-isothiocyanatopropan-1-ones