English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

4a-Methyl-2,3,3,4a-tetrahydro-1H-carbazole (3), obtained from phenylhydrazinium chloride and 2-methylcyclohexanone, was regioselectively reduced with sodium borohydride to 4a-methyl-2,3,4,4a,9a-hexahydro-1H-carbazole (4). Cyclocondensation of hexahydrocarbazole 4 with 2 molecules of diethyl malonate 5a gives 7-hydroxy-13a-methyl-9a,10,11,12,13,13a-hexahydro-5H,8H-pyrano[2',3':4,5] pyrido[3,2,1-jk]carbazole-5,8-dione (6), which affords in a 2-step degradation 5-unsubstituted 4-hydroxy-11a-methyl-7a,8,9,10,11,11a-hexahydro-6H-pyrido[3,2,1-jk]carbazol-6-one (9). Nitration of 9 forms the 5-nitro compound 12, which cyclized after chlorination and azidation at position 4 on thermolysis to the 12a-methyl-7-oxo-8a,9,10,11,12,12a-hexahydro-7H-[1,2,5]oxadiazolo[3',4':4,5]pyrido[3,2,1-jk] carbazol-6-oxide 15. Cyclocondensation of hexahydrocarbazole 4 with phenylmalonate 5b forms 4-hydroxy-11a-methyl-5-phenyl-7a,8,9,10,11,11a-hexahydro-6H-pyrido[3,2,1-jk]carbazol-6-one (16a), which cyclized after chlorination and azidation at position 4 on thermolysis to the 3b-methyl-3b,4,5,6,7,7a-hexahydroindolo[2',3':4,5]pyrido[3,2,1-jk]carbazol-9(14H)-one derivative 19. The conditions in the thermolytical decomposition and cyclization of the azido compounds were investigated by differential thermal analysis (DSC).

Syntheses, Substitution and Cyclization Reactions of 7a,8,9,10,11a-Hexahydro-pyrido[3,2,1-jk]carbazoles With a Strychnos Alkaloids Partial Structure