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In the present study, a series of new N-alkyl-N-(piperidin-1-yl)benzenesulfonamide (1a-f) and Naryl/alkyl substitued-2-[(phenylsulfonyl)(piperidin-1-yl)amino]acetamide (3a-n) derivatives were synthesized. These derivatives were prepared by reacting 1-amino piperidine with benzene sulfonyl chloride to afford parent compound N-(piperidin-1-yl)benzenesulfonamide (1), followed by substitution at nitrogen with different electrophilic reagents in the presence of sodium hydride to give a series of derivatives 1a-f and 3a-n. The structures of the synthesized compounds were confirmed based on 1 H-NMR, IR and mass spectral data. The synthesized compounds were screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and almost all the compounds exhibited promising activities.

Synthesis of Bioactive Sulfonamides Bearing Piperidine Nucleus with Talented Activity Against Cholinesterase