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Magnetic Drug Targeting is a promising cancer treatment that offers the possibility of increasing therapeutic efficiency while reducing the patient’s side-effects. Thereby, the cancer-drug is bounded to magnetic nanoparticles, which are injected into a vessel and guided through the cardiovascular system into the tumor by an external magnetic field. However, a successful navigation depends on several multiphysical parameters including the properties of the nanoparticles, the flow characteristics of blood, and the gradient of the applied magnetic field. To investigate their impact, the propagation of particle packets within a 45∘ bifurcation vessel was modeled in COMSOL Multiphysics®. Therefore, magnets with varying radius-to-length ratios and magnetizations (radial and axial) were placed right before the bifurcation. Furthermore, different fluid velocities in addition to the influence of the gravitational force were evaluated. Overall, a strong dependency of the particle steering on the fluid velocity and the magnet’s radius-to-length ratio was observed. Moreover, a radial magnetization has a greater impact on the particle propagation, while the gravitation can be neglected for higher velocities. However, when a single permanent magnet is used, the results depict that it is a fine line between deflecting or trapping a particle at the vessel wall.

Investigation of Particle Steering for Different Cylindrical Permanent Magnets in Magnetic Drug Targeting