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Stimuli Sensitive hydrogels have enormous potential in various applications. Various environmental variables are found in the body, such as low pH and elevated temperatures. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. For many applications hydrogels require a very rapid time-response in terms of their sensitivity to either pH and/or temperature. Rapid time-responsive sensitivity is a research field which is still in development. In this research pH-sensitive hydrogels have been made varying the composition and molecular weight of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA). After total dissolution of the PVA/PAA the hydrogel was freeze/thawed. The swelling responses were investigated as well as the drug release profile with varying pH. The drug release was studied with a model drug theophylline. The characteristic properties were examined with ac impedance. The results showed that the optimum formulation to be used as a stimulus sensitive hydrogel is found with lower concentration of PVA and a higher concentration of PAA. These PVA/PAA hydrogels have potential in biomedical applications.

Preparation and Characterization of Novel Poly(Vinyl Alcohol) (PVA) and Poly(Acrylic Acid) (PAA) Hydrogels for Sensitive Hydrogels