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Living systems display a variety of situations in which non-equilibrium fluctuationscouple to certain protein functions yielding astonishing results. Here we study the bacterial channelOmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are knownto yield oscillations in the electric potential across the cell membrane. We use a three-dimensionalstructure-based theoretical approach to assess the possibility of obtaining fluctuation-driven transport.Our calculations show that remarkably high voltages would be necessary to observe the actualtransport of ions against their concentration gradient. The reasons behind this are the mild selectivityof this bacterial pore and the relatively low efficiencies of the oscillating signals characteristic ofmembrane cells (random telegraph noise and thermal noise)

Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study