English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

18 F-FDG Positron Emission Tomography (PET) is used to monitor tumor response to 131 I-therapy, but is confounded by prompt emissions (284, 364, 637, and 723 keV) from 131 I, particularly in animal PET imaging. We propose a method for correcting this emission in 18 F-FDG PET. The 131 I prompt emission effect was assessed within various energy windows and various activities. We applied a single gamma correction method to a phantom and in vivo mouse model. The 131 I prompt emission fraction was 12% when 300 µCi of 131 I and 100 µCi of FDG were administered, and increased exponentially with escalating 131 I activity for all energy windows. The difference in spill-over ratio was reduced to &lt;5% after 131 I prompt emission correction. In the mouse model, the standard uptake value (SUV) did not differ significantly between FDG PET only (gold standard) and FDG PET after 131 I prompt emission-correction, whereas it was overestimated by 38% before correction. Contrast was improved by 18% after 131 I prompt emission correction. We first found that count contamination on 18 F-FDG follow-up scans due to 131 I spilled-over count after 131 I rituximab tumor targeted therapy. Our developed 131 I prompt emission-correction method increased accuracy during measurement of standard uptake values on 18 F-FDG PET.

Improved Quantification of 18F-FDG PET during 131I-Rituximab Therapy on Mouse Lymphoma Models after 131I Prompt Emission Correction