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Asthma may have an impact on lung function decline but conflicting results are reported in forced expiratory volume in one second (FEV 1 ) decline. We aimed to describe the changes in FEV 1 in lifelong non-smoking adult asthmatic outpatients during a 10-year follow-up comparing years 1-5 (1st period) with years 6-10 (2nd period) to assess factors affecting these changes. A total of 100 outpatients performed spirometry every 3 months during a 10-year survey. FEV 1 /Ht 3 slope values of the 2nd period reduced significantly respect to the 1st period ( p &lt; 0.0001). FEV 1 slopes of years 1-5 and 6-10 were inversely associated with FEV 1 at enrolment ( p = 0.02, p = 0.01, respectively). Reversibility and variability FEV 1 showed a significant effect on the 1st period slopes ( p = 0.01 and p &lt; 0.04, respectively). Frequent exacerbators in the 1st year had steeper FEV 1 /Ht 3 slopes in the 1st period ( p = 0.01). The number of subjects using higher doses of ICS was significantly lower at the 10th years respect to the 5th and the 1st year ( p &lt; 0.001, p = 0.003, respectively). This study shows that FEV 1 decline in treated adult asthmatics non-smokers, over 10-year follow-up, is not constant. In particular, it slows down over time, and is influenced by FEV 1 at enrolment, reversibility, variability FEV 1 and exacerbation score in the 1st year.

Lung Function Decline in Adult Asthmatics—A 10-Year Follow-Up Retrospective and Prospective Study