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To compare different parameters of the sphericity index of the ablation zone following microwave ablation (MWA) on cirrhotic- and healthy-liver parenchyma in a series of patients treated with the same MWA system. Institutional database research identified 46 patients (77 lesions) who underwent MWA. “Cirrhotic liver group” (CLG) included 35 hepatocellular carcinoma lesions; “healthy liver group” (HLG) included 42 metastatic lesions. The long axis (LAD), short axis 1 (SAD-1) and 2 (SAD-2), the mean SAD-1 and SAD-2 (mSAD) diameter (in mm) and the mean sphericity (mSPH) index of the ablation zones were evaluated for each treated lesion in both groups from baseline to follow-up. A mixed model analysis of variance reported significant main effect of group on SAD-1 ( p  = 0.023), SAD-2 ( p  = 0.010) and mSAD ( p  = 0.010), with HLG showing lower values compared to CLG. No differences were detected on the LAD (p FDR  = 0.089; d = 0.45), and mSPH (p FDR  = 0.148, d = 0.40) between the two groups. However, a significant main effect of time was found on LAD ( p  < 0.001), SAD-1 ( p  < 0.001), SAD-2 ( p  < 0.001) and mSAD ( p  < 0.001), with decreased values in all indices at follow-up compared to baseline. A significant group by time interaction was observed on mSPH ( p  = 0.044); HLG had significantly lower mSPH at follow-up where CLG did not show any significant change. Our findings indicate that although in cirrhotic liver short axis diameter of the MWA zone seems to be significantly longer, this has no effect on the sphericity index which showed no significant difference between cirrhotic vs. healthy liver lesions. On the contrary, on one month follow-up ablation zones tend to become significant more ellipsoid in healthy whilst remains stable in cirrhotic liver.

diagnostics

Percutaneous Microwave Ablation of Liver Lesions: Differences on the Sphericity Index of the Ablation Zone between Cirrhotic and Healthy Liver Parenchyma