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Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. Results:  Wisteria floribunda  agglutinin-positive human Mac-2 binding protein (WFA + –M2BP) levels increased according to the grade of GEV (3.4 (0.2–18.6) for no GEV, 7.9 (1.8–20.0) for small GEV, and 11.4 (4.0–20.0) for large GEV;  p  < 0.001). The diagnostic accuracy of the WFA + –M2BP was superior compared to other serum fibrosis markers, and WFA + –M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA + –M2BP levels ≤ 7.0 and 37.5% in patients with WFA + –M2BP levels > 7.0 ( p  < 0.001). WFA + –M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7,  p  = 0.004) independent of Child–Pughclass. Conclusions: WFA + –M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.

diagnostics

Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients