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Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin's lymphoma that occurs in the central nervous system. Although sensitive to chemotherapy, 35-60% of PCNSL patients still relapse within 2 years after the initial treatment. High-dose methotrexate (HD-MTX) rechallenge is generally used in recurrent PCNSL, especially for patients who have achieved a response after initial methotrexate (MTX) treatment. However, the overall remission rate (ORR) of HD-MTX rechallenge is about 70-80%. Additionally, the side effects of HD-MTX treatment endanger the health of patients and affect their quality of life.

current oncology

Analysis of Key Factors Associated with Response to Salvage High-Dose Methotrexate Rechallenge in Primary Central Nervous System Lymphoma with First Relapse