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Vitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor ( VDR ) polymorphisms ( ApaI,   FokI ,  TaqI ,  BsmI , and  BglI ) and the risk of dental caries in children. Methods: PubMed/MEDLINE, Cochrane Library, Web of Science, and Scopus databases were comprehensively searched until 19 January 2021. Meta-analysis with odds ratios as the effect estimate along with 95% confidence intervals and subgroup analysis were conducted using Review Manager 5.3 software. Publication bias and sensitivity analyses were conducted by Comprehensive Meta-Analysis, version 2.0 software. Results: Seventy-eight studies were retrieved from the databases, with nine studies included in the final analysis. Based on five genetic models, there was no association between  ApaI (rs7975232) ,  TaqI (rs731236) ,  BsmI (rs1544410) ,  FokI (rs2228570) , and  BglI (rs739837)  polymorphisms and susceptibility to dental caries, except for the  FokI (rs10735810)  polymorphism. Conclusion: Among the  VDR  polymorphisms considered, an association was found between the  FokI (rs10735810)  polymorphism and the risk of dental caries, with a protective role of the f allele and ff genotype.

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The Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and Meta-Analysis