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There is significant demand for portable sensors that can deliver selective and sensitive measurement of ethanol on-site. Such sensors have application across many industries, including clinical and forensic work as well as agricultural and environmental analysis. Here, we report a new graphene–indium oxide electrochemical sensor for the determination of ethanol in aqueous samples. Graphene layers were functionalised by anchoring In2O3 to its surface and the developed composite was used as a selective electrochemical sensor for sensing ethanol through cyclic voltammetry. The detection limit of the sensor was 0.068 mol/L and it showed a linear response to increasing ethanol in the environment up to 1.2 mol/L. The most significant parameters involved and their interactions in the response of the sensor and optimization procedures were studied using a four-factor central composite design (CCD) combined with response surface modelling (RSM). The sensor was applied in the detection of ethanol in authentic samples.

Introducing Graphene–Indium Oxide Electrochemical Sensor for Detecting Ethanol in Aqueous Samples with CCD-RSM Optimization