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The lethal-7 (let  -7  ) family is an important microRNA (miRNA) group that usually exerts functions as a tumor suppressor. We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g , and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. The miRNAs expression profile was assessed in 34 LMS and 13 normal myometrium (MM) paraffin-embedded samples. All let-7 family members showed downregulation in LMS. Our findings showed that patients with let-7e downregulation had worse overall survival (OS) and is an independent prognostic factor (hazard ratio [HR] = 2.24 ). In addition, almost half the patients had distant metastasis . LMS patients with downregulated let-7b and let-7d had worse disease-free survival (DFS); they are not independent prognostic factors (HR = 2.65 ). Patients' ages were associated with let-7d, let-7e and let-7f (p = 0.0160 ) downregulation. In conclusion, all the let-7 family members were downregulated in LMS patients, and the greater the loss of expression of these molecules, the greater their relationship with worse prognosis of patients. L  et-7e expression might influence the OS, while let-7b and le-7d might influence the DFS. The l owest expression levels of l  et-7d, let-7e , and let-7f were associated with the oldest patients. Our findings indicate strong evidence of let-  7 ' s role as a potential prognostic biomarker in LMS.

Let-7 miRNA’s Expression Profile and Its Potential Prognostic Role in Uterine Leiomyosarcoma