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The kinetics of antigen-presenting cells (APCs) vary depending on their resident tissues and the manner of immunization. We investigated the long-term changes in mature APC and T-cell subsets over 4 weeks in the ocular surface in murine models of corneal quiescent or potent sterile inflammation, and allosensitization using partial (PT), syngeneic (Syn), and allogeneic (Allo) corneal transplantation. In PT, CD11b int CD11c hi MHCII hi CD86 hi cells increased until 4 weeks with an increase in IFNγ hi T cells. In Syn, both CD11b int CD11c hi MHCII hi CD86 hi and CD11b hi CD11c hi MHCII hi CD86 hi APC subsets increased until 4 weeks with a brief increase in CD69 hi T cells at 2 weeks. In Allo, CD11b int CD11c hi MHCII hi CD86 hi and CD11b hi CD11c hi MHCII hi CD86 hi APC subsets increased until 4 weeks, and an early increase in CD69 hi T cells was observed at 2 weeks followed by a late increase in IFNγ hi T cells at 4 weeks. The frequency of the IFNγ hi T cell subset was positively correlated with the frequency of the CD11b int CD11c hi MHCII hi CD86 hi subset, indicating the existence of APC-T cell interaction in the ocular surface. Together, the results indicate that allosensitization in mature APCs leads to T-cell activation in the ocular surface, whereas sterile inflammation merely induces a brief and non-specific T-cell activation in the ocular surface.

cells

Time-Dependent Serial Changes of Antigen-Presenting Cell Subsets in the Ocular Surface Are Distinct between Corneal Sterile Inflammation and Allosensitization in a Murine Model