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Simple Summary  Idiopathic pulmonary fibrosis (IPF) patients have a significantly higher risk of developing lung cancer. Traditional risk factors including age, male gender, smoking status, and emphysema have been reported. However, there are only limited data on radiomics features from HRCT images useful for risk stratification of IPF patients for lung cancer. In this study, we found that texture-based radiomics features can be differentiated between IPF patients with and without cancer development, and their diagnostic accuracy is not inferior to that of traditional risk factors. By combining radiomics features and traditional risk factors, the diagnostic accuracy can be improved.    Abstract  Idiopathic pulmonary fibrosis (IPF) patients have a significantly higher risk of developing lung cancer (LC). There is only limited evidence of the use of texture-based radiomics features from high-resolution computed tomography (HRCT) images for risk stratification of IPF patients for LC. We retrospectively enrolled subjects who suffered from IPF in this study. Clinical data including age, gender, smoking status, and pulmonary function were recorded. Non-contrast chest CT for fibrotic score calculation and determination of three dimensional measures of whole-lung texture and emphysema were performed using a promising deep learning imaging platform. The results revealed that among 116 subjects with IPF (90 non-cancer and 26 lung cancer cases), the radiomics features showed significant differences between non-cancer and cancer patients. In the training cohort, the diagnostic accuracy using selected radiomics features with AUC of 0.66–0.73 (sensitivity of 80.0–85.0% and specificity of 54.2–59.7%) was not inferior to that obtained using traditional risk factors, such as gender, smoking status, and emphysema (%). In the validation cohort, the combination of radiomics features and traditional risk factors produced a diagnostic accuracy of 0.87 AUC and an accuracy of 75.0%. In this study, we found that whole-lung CT texture analysis is a promising tool for LC risk stratification of IPF patients.

Quantification of Cancer-Developing Idiopathic Pulmonary Fibrosis Using Whole-Lung Texture Analysis of HRCT Images