Open AccessOncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer
Author(s) -
Maria Radanova,
Galya Mihaylova,
Neshe Nazifova-Tasinova,
Mariya Levkova,
Oskan Tasinov,
Desislava Ivanova,
Zornitsa Mihaylova,
Ivan Donev
Publication year - 2021
Publication title -
cancers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.818
H-Index - 76
ISSN - 2072-6694
DOI - 10.3390/cancers13143395
Subject(s) - colorectal cancer , disease , medicine , metastasis , bioinformatics , cancer , mechanism (biology) , oncology , cancer research , biology , philosophy , epistemology
Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients.