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Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with relapse occurring in about 70% of advanced cases with poor prognosis. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT ( 18 F-FDGPET/CT) is the most specific radiological imaging used to assess recurrence. Some intensity-based and volume-based PET parameters, maximum standardized uptake values (SUV max ), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are indicated to have a correlation with treatment response. The aim of our study is to correlate these parameters with post relapse survival (PRS) and overall survival (OS) in Epithelial Ovarian Cancer (EOC) relapse. The study included 50 patients affected by EOC relapse who underwent 18 F-FDGPET/CT before surgery. All imaging was reviewed and SUV max , MTV and TLG were calculated and correlated to PRS and OS. PRS and OS were obtained from the first relapse and from the first diagnosis to the last follow up or death, respectively. SUV max , MTV and TLG were tested in a univariate logistic regression analysis, only SUV max demonstrated to be significantly associated to PRS and OS ( p = 0.005 and p = 0.024 respectively). Multivariate analysis confirmed the results. We found a cut-off of SUV max of 13 that defined worse or better survival ( p = 0.003). In the first relapse of EOC, SUV max is correlated to PRS and OS, and when SUV max is greater than 13, it is an unfavorable prognostic factor.

Potential Prognostic Role of 18F-FDG PET/CT in Invasive Epithelial Ovarian Cancer Relapse. A Preliminary Study