English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In this simulation study, we assessed differences in gross tumor volume (GTV) in a series of skull base paragangliomas (SBPGLs) using magnetic resonance imaging (MRI), 18 F-dihydroxyphenylalanine ( 18 F-FDOPA) combined positron emission tomography/computed tomography (PET/CT), and 18 F-FDOPA PET/MRI images obtained by rigid alignment of PET and MRI. GTV was delineated in 16 patients with SBPGLs on MRI (GTV MRI ), 18 F-FDOPA PET/CT (GTV PET ), and combined PET/MRI (GTV PET/MRI ). GTV PET/MRI was the union of GTV MRI and GTV PET after visual adjustment. Three observers delineated GTV MRI and GTV PET/MRI independently. Excellent interobserver reproducibility was found for both GTV MRI and GTV PET/MRI . GTV PET and GTV MRI were not significantly different. However, there was some spatial difference between the locations of GTV MRI , GTV PET , and GTV PET/MRI . The Dice similarity coefficient median value was 0.4 between PET/CT and MRI, and 0.8 between MRI and PET/MRI. The combined use of PET/MRI produced a larger GTV than MRI alone. Nevertheless, both the target-delivered dose and organs-at-risk conservancy were respected when treatment was planned on the PET/MRI-matched data set. Future integration of 18 F-FDOPA PET/CT into clinical practice will be necessary to evaluate the influence of this diagnostic modality on SBPGL therapeutic management. If the clinical utility of 18 F-FDOPA PET/CT and/or PET/MRI is confirmed, GTV PET/MRI should be considered for tailored radiotherapy planning in patients with SBPGL.

18F-FDOPA PET/CT Combined with MRI for Gross Tumor Volume Delineation in Patients with Skull Base Paraganglioma